P-8: Protective Effect of Royal Jelly versus Vitamin C against Anemia-Induced Damages in Testicular Tissue

نویسندگان

  • Malekinejad H
  • Razi M
  • Shahrooz R
چکیده مقاله:

Background: Phenylhydrazine (PHZ) is used to induce experimental anemia in animal models. On the other hand royal jelly is known as antioxidant compound. Therefore, here in present study we aimed to evaluate the protective effect of royal jelly on PHZ-induced damages in testicular tissue and compare its impact with vitamin C. Materials and Methods: Eighteen mature male mice were randomly divided into 3 groups. In order to induce experimental anemia, PHZ was administrated at dose of 8 mg/kg, ip and then it was continued as 6 mg/kg, every 48 hours, ip in all groups. The test groups subdivided into non-treated PHZ-received, royal jellyreceived (100 mg/kg, orally) and vitamin C-received (250 mg/kg, ip). After 35 days, the Leydig Cells steroidogenic Activity was evaluated by using special fluorescent staining for intra-cytoplasmic steroid foci and analyzing serum level of testosterone. The spermiogenesis index and germinal epithelium RNA damage were assessed. Finally, tissue levels of total antioxidant capacity (TAC) and total thiol molecules (TTM) were investigated. Results: Observations demonstrated that PHZ resulted in significant (p<0.05) reduction in Leydig cells steroidogenic Foci ratio. Meanwhile, royal jelly enhanced the intra-cytoplasmic steroid accumulation and elevated serum level of testosterone versus nontreated animals. There were no significant differences between vitamin C and royal jelly. Moreover, royal jelly-treated animals exhibited remarkably lower percentage of tubules with damages RNA as well as increased tissue TAC and TTM ratio. Conclusion: Our data showed that royal jelly by enhancing the antioxidant status of the testicular tissue inhibited the PHZ-induced RNA damage and up-regulated the testicular endocrine activity.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protective Effect of Royal Jelly against Renal Damage in Streptozotocin Induced Diabetic Rats

Background: Royal jelly has been shown to have antioxidant and antidiabetic effects. The objective of this study was to evaluate the protective effect of RJ against kidney damage in streptozotocin induced diabetic rats. Methods: Thirty two male Wistar rats were divided randomly into four groups (n=8 per group). Normal control and diabetic control groups received 1cc/day distilled water, norm...

متن کامل

Protective effects of royal jelly against testicular damage in streptozotocin-induced diabetic rats.

BACKGROUND/AIM TO examine the effects of royal jelly (RJ) on testicular damage in streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS Eighteen adult Wistar albino rats were used, 6 in each of the 3 treatment groups: Group A: control, Group B: STZ-induced diabetes (untreated), Group C: STZ-induced diabetes plus RJ (400 mg/kg daily for 4 weeks). Diabetes was induced by a single in...

متن کامل

P-86: Protective Effect of Vitamin C and Royal Jelly on Sex Hormones on Phenylhydrazine Treated Adult Male Mice

Background: Phenylhydrazine (PHZ) is used to induce experimental anemia in animal models. On the other hand royal jelly is known as antioxidant compound. Therefore, here in present study we aimed to evaluate the protective effect of royal jelly on PHZ-induced damages in testicular tissue and compare its impact with vitamin C. Materials and Methods: Eighteen mature male mice were randomly divide...

متن کامل

مطالعه اثرات محافظتی ژل رویال و ویتامین C در برابر آنمی همولیتیک تجربی بر هورمون‌های جنسی و هیستوشیمی بافت بیضه موش‌های سفید آزمایشگاهی بالغ

Introduction: Phenylhydrazine (PHZ) is a well-known hemolytic compound inducing intoxication in erythrocytes. Therefore, the present study aimed to evaluate the protective effects of royal jelly and vitamin C against phenylhydrazine-induced damages in mouse testicles. Methods: In this study, 64 adult male mice were randomly and equally assigned to eight groups. The first group received norma...

متن کامل

P-25: Royal Jelly Protects from The Paclitaxel-Induced Damages on Sperm Quality in Rats

Background: Paclitaxel (Taxol, TXL) is a chemotherapy agent which widely used in the treatment of tumors, such as lung cancer, breast and prostatic cancer. Previous reports indicate that taxol damages mainly dividing cells (spermatogonias and spermatocytes) and postmeiotic epitheliocytes (spermatids and spermatozoa). The toxic effect of the drug on microtubules underlies its antiproliferative e...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 8  شماره 2.5

صفحات  31- 31

تاریخ انتشار 2014-07-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023